Recombinant Human FcRn Protein
$550.00
Syd Labs Recombinant Human FcRn Protein BP4095, Recombinant human FcRn protein is the full length FcRn protein fused with a polyhistidine tag at the C-terminus.
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Catalog No. | BP4095 |
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Product Name | Recombinant Human FcRn Protein |
Supplier Name | Syd Labs, Inc. |
Brand Name | Syd Labs |
Synonyms | Neonatal Fc receptor |
Source | HEK 293 cell-derived. |
Formulation | 0.2 μM filtered solution of 20 mM Hepes, 150 mM NaCl, pH 7.5. |
Endotoxin | Less than 1 EU/ug of protein as determined by LAL method. |
Shipping | The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
Note | Conditions of optimal recombinant human FcRn protein performance should be determined experimentally by the investigator. |
Order Offline | Phone: 1-617-401-8149Fax: 1-617-606-5019Email: message@sydlabs.comOr leave a message with a formal purchaseorder (PO) Or credit card. |
Description
BP4095: Recombinant Human FcRn Protein
Background
The neonatal Fc receptor (FcRn) is responsible for transporting maternal IgGs to fetus/newborns and maintaining the homeostasis of IgGs in adults. FcRn resembles class I major histocompatibility complex in structure, and is composed of a transmembrane heavy chain and an invariant β2 microglobulin. Changes in the affinity of IgGs to FcRn lead to changes in the half-life of engineered IgGs and Fc fusion proteins. Longer half-life of therapeutic antibodies means lower dose and longer interval between administering. For some diagnostic agents, including imaging or radio-labeled agents, a shorter half-life in circulation results in lower non-specific binding and decreased side effects. Therefore, studying the interaction of FcRn and therapeutic antibodies has direct clinical implications.
BP4095: Recombinant human FcRn protein
Source: HEK 293 cell-derived.
Recombinant human FcRn protein is the FcRn (Ala24 – Ser297) and B2M (β2 Microglobulin) fusion protein with Myc tag and His tag at the C-terminus.
Activity: Recombinant human FcRn protein binds to human IgG in a pH dependent manner.
Formulation: 0.2 μM filtered solution of 20 mM Hepes, 150 mM NaCl, pH 7.5.
Endotoxin Level: Less than 1 EU/ug of protein as determined by LAL method.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month from date of receipt, 2 to 8°C as supplied.
3 months from date of receipt, -20°C to -70°C as supplied.
Please remember our product information: Recombinant Human FcRn Protein: BP4095 Syd Labs