Mouse WISP1 Protein (WIP-MM101)
$270.00 – $900.00
KACTUS Biosystems Mouse WISP1 Protein (WIP-MM101) (catalog No. WIP-MM101) is expressed from HEK293 with His tag at the C-Terminus.It contains Thr23-Asn367.
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| Catalog No. | WIP-MM101 |
|---|---|
| Product Name | Mouse WISP1 Protein (WIP-MM101) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Synonyms | ELM-1; WISP-1; CCN4; WISP1c; WISP1i; WISP1tc |
| Species | Mouse |
| Source | HEK293 |
| Accession | O54775 |
| Product Tag | C-His |
| Biotinylated | no |
| Exact Sequence | Thr23-Asn367 |
| Molecular Weight | The protein has a predicted MW of 39.4 kDa. Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | '-20 to -80°C for 12 months as supplied from date of receipt.；-20 to -80°C for 3-6 months in unopened state after reconstitution.；2-8°C for 2-7 days after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
WIP-MM101: Mouse WISP1 Protein (WIP-MM101)
The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.
Please remember our product information: Mouse WISP1 Protein (WIP-MM101) catalog number: WIP-MM101 KACTUS Biosystems