Human PBK/TOPK Protein (PBK-HB101)
$283.50 – $945.00
KACTUS Biosystems Human PBK/TOPK Protein (PBK-HB101) (catalog No. PBK-HB101) is expressed from Baculovirus-Insect Cells with His tag at the C-terminal.It contains Met1-Val322.
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| Catalog No. | PBK-HB101 |
|---|---|
| Product Name | Human PBK/TOPK Protein (PBK-HB101) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Species | Human |
| Source | Baculovirus-Insect Cells |
| Accession | Q96KB5-1 |
| Product Tag | C-His |
| Biotinylated | no |
| Exact Sequence | Met1-Val322 |
| Molecular Weight | The protein has a predicted MW of 37.61 kDa. Due to glycosylation, the protein migrates to 38-45 kDa based on Tris-Bis PAGE result. |
| Form | Liquid |
| Formulation | Supplied as 0.22μm filtered solution in PBS (pH 7.4). |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped with dry ice. |
| Stability & Storage | Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PBK-HB101: Human PBK/TOPK Protein (PBK-HB101)
T-lymphokine-activated killer cell-originated protein kinase (TOPK, also known as PDZ-binding kinase or PBK) plays a crucial role in cell cycle regulation and mitotic progression. Abnormal overexpression or activation of TOPK has been observed in many cancers, including colorectal cancer, triple-negative breast cancer, and melanoma, and it is associated with increased development, dissemination, and poor clinical outcomes and prognosis in cancer. Moreover, TOPK phosphorylates p38, JNK, ERK, and AKT, which are involved in many cellular functions, and participates in the activation of multiple signaling pathways related to MAPK, PI3K/PTEN/AKT, and NOTCH1.
Please remember our product information: Human PBK/TOPK Protein (PBK-HB101) catalog number: PBK-HB101 KACTUS Biosystems