Human Kallikrein 5/KLK5 Protein (KLK-HM105)
$270.00 – $900.00
KACTUS Biosystems Human Kallikrein 5/KLK5 Protein (KLK-HM105) (catalog No. KLK-HM105) is expressed from HEK293 with His tag at the C-Terminus.It contains Val23-Ser293.
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| Catalog No. | KLK-HM105 |
|---|---|
| Product Name | Human Kallikrein 5/KLK5 Protein (KLK-HM105) |
| Supplier Name | KACTUS Biosystems |
| Brand Name | KACTUS Biosystems |
| Synonyms | Kallikrein c; Klnc; KLK5; KLKL2; KLK-L2; SCTE |
| Species | Human |
| Source | HEK293 |
| Accession | Q9Y337 |
| Product Tag | C-His |
| Biotinylated | no |
| Exact Sequence | Val23-Ser293 |
| Molecular Weight | The protein has a predicted MW of 30.7 kDa. Due to glycosylation, the protein migrates to 42-48 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| Formulation | Lyophilized from 0.22μm filtered solution in 50mM MES, 150mM NaCl (pH 5.5). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM MES, 150mM NaCl (pH 5.5). |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per μg by the LAL method. |
| Shipping | Shipped at ambient temperature. |
| Stability & Storage | '-20 to -80°C for 12 months as supplied from date of receipt.；-20 to -80°C for 3-6 months in unopened state after reconstitution.；2-8°C for 2-7 days after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
KLK-HM105: Human Kallikrein 5/KLK5 Protein (KLK-HM105)
The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.
Please remember our product information: Human Kallikrein 5/KLK5 Protein (KLK-HM105) catalog number: KLK-HM105 KACTUS Biosystems
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 500 ug |