Glucocorticoid Receptor Rabbit mAb
$148.00 – $548.00
GR; GCR; GRL; GCCR; GCRST
- Details & Specifications
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| Catalog No. | A19583 |
|---|---|
| Product Name | Glucocorticoid Receptor Rabbit mAb |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | GR; GCR; GRL; GCCR; GCRST |
| Gene Name | NR3C1 |
| Protein Name | NR3C1 |
| Uniprot/Swissprot ID | P04150 |
| Entrez GeneID | 2908 |
| Clone | ARC0062 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Applications | WB, IP |
| Reactivity | Human, Mouse, Rat |
| Conjugate | Unconjugated |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
