E-Cadherin Mouse mAb
$148.00 – $548.00
UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324
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| Catalog No. | A18135 |
|---|---|
| Product Name | E-Cadherin Mouse mAb |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324 |
| Gene Name | CDH1 |
| Protein Name | CDH1 |
| Uniprot/Swissprot ID | P12830 |
| Entrez GeneID | 999 |
| Clone | AMC0113 |
| Clonality | Monoclonal |
| Source/Host | Mouse |
| Applications | WB, IF/ICC |
| Reactivity | Human, Mouse |
| Conjugate | Unconjugated |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.