Doublecortin Rabbit mAb
$148.00 – $548.00
DC; DBCN; LISX; SCLH; XLIS
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| Catalog No. | A19042 |
|---|---|
| Product Name | Doublecortin Rabbit mAb |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | DC; DBCN; LISX; SCLH; XLIS |
| Gene Name | DCX |
| Protein Name | DCX |
| Uniprot/Swissprot ID | O43602 |
| Entrez GeneID | 1641 |
| Clone | ARC0380 |
| Clonality | Monoclonal |
| Source/Host | Rabbit |
| Applications | WB |
| Reactivity | Mouse, Rat |
| Conjugate | Unconjugated |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia (“double cortex” syndrome) in females and lissencephaly (“smooth brain” syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
