CD74 Unconjugated(108801)
$110.00 – $390.00
Caprico Biotechnologies CD74 Unconjugated catalog number: 108801，PIN.1 recognizes a ~33-35 kDa protein doublet, corresponding to the apparent molecular mass of the p33 and p35 forms of the cytoplasmic tail of human CD74, a type II transmembrane glycoprotein.
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| Catalog No. | 108801 |
|---|---|
| Product Name | CD74 Unconjugated(108801) |
| Supplier Name | Caprico Biotechnologies, Inc. |
| Brand Name | Caprico |
| Accession No. | NC_000005.10 |
| Protein Name | CD74 |
| Uniprot/Swissprot ID | P04233 |
| Gene ID | 972 |
| Primary/Secondary | Primary |
| Clone | PIN.1 |
| Clonality | Monoclonal |
| Source/Host | Mouse |
| Reactivity | Human |
| Immunogen | An EBV-transformed B cell line from a patient with MHC class II deficiency |
| Form Of Antibody | PBS pH 7.2, 0.1% (w/v) BSA, 0.09% (w/v) sodium azide |
| Conjugate | Unconjugated |
| Purity | >95% |
| Stability & Storage | 2-8oC |
| Note | Products will be shipped from the warehouse in Georgia. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5165 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card. |
Description
108801：CD74 Unconjugated(108801)
PIN.1 recognizes a ~33-35 kDa protein doublet, corresponding to the apparent molecular mass of the p33 and p35 forms of the cytoplasmic tail of human CD74, a type II transmembrane glycoprotein. It is also known as invariant chain or MHC class II chaperone or MIF (macrophage migration inhibitory factor) receptor. It plays a critical role in the antigen processing leading to antigen presentation by MHC class II to CD4+ T cells. Antigen presenting cells such as B cells, monocytes/macrophages, dendritic cells, and Langerhans cells as well as activated T, carcinomas of lung, renal, gastric and thymic origins express CD74. The CD44 is an integral member of CD74 receptor complex and required for the CD74 signal transduction. CD74’s cytoplasmic domain binds chromatin and regulates transcription and expression of genes involved in immune regulation, cell survival, and hematopoietic cancers. Published report claimed that the urease B subunit released by H. pylori binds to CD74 of gastric epithelial cells leading to induce NF-κB activation and IL-8 production.
Please remember our product information: CD74 Unconjugated(108801) catalog number: 108801 Caprico Biotechnologies