Adalimumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
$375.00
Adalimumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant. Adalimumab biosimilar CHO stable cell line is available for licensing to manufacture the adalimumab biosimilar protein.The research grade adalimumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available.
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Catalog No. | C003P.LA |
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Product Name | Adalimumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
Supplier Name | Syd Labs, Inc. |
Brand Name | Syd Labs |
Synonyms | Anti-TNF alpha Human Monoclonal Antibody |
Summary | Recombinant Humanized IgG1 Monoclonal Antibody. |
Source/Host | The monoclonal antibody adalimumab biosimilar was produced in the adalimumab biosimilar CHO stable cell line. |
Specificity/Sensitivity | The monoclonal antibody adalimumab biosimilar specifically binds to the human TNF alpha. |
Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by adalimumab. |
Form Of Antibody | 0.2 uM filtered solution, pH 5.2, no stabilizers or preservatives. |
Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
Shipping | The Adalimumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
Note | Adalimumab biosimilar CHO stable cell line is available for licensing to manufacture the adalimumab biosimilar protein.The research grade adalimumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. |
Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Orleave a message with a formal purchase order (PO) Or credit card. |
Description
C003P.LA: Adalimumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
Adalimumab, the first fully human monoclonal antibody drug approved by FDA, binds to TNFα, inactivates TNF receptors, and downregulates the inflammatory reactions associated with a variety of autoimmune diseases, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, moderate to severe chronic psoriasis and juvenile idiopathic arthritis.
Mainly produced by activated macrophages (M1), Tumor necrosis factor (TNF, cachexin, cachectin, tumor necrosis factor alpha, TNFα) plays important roles in the regulation of immune cells. As a member of a group of cytokines that stimulate the acute phase reaction, TNF is involved in systemic inflammation and able to induce fever, apoptotic cell death, cachexia, inflammation, and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF expression could have serious impact in a variety of human diseases including Alzheimer’s disease, cancer, major depression and inflammatory bowel disease.
Syd Labs also provides the following anti-TNF antibody biosimilar protein:
Infliximab biosimilar, research grade
Syd Labs also provides the following research grade antibody biosimilar proteins:
Bevacizumab Biosimilar, research grade (VEGF-A)
Ranibizumab Biosimilar, research grade (VEGF-A, Fab produced in E. coli)
Cetuximab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Panitumumab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Trastuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Pertuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Infliximab biosimilar, research grade (TNF alpha)
Adalimumab biosimilar, research grade (TNF alpha)
Rituximab biosimilar, research grade (CD20)
Denosumab biosimilar, research grade (RANKL, RANK ligand, OPGL, TNFSF11, CD254, TRANCE, ODF)
Palivizumab Biosimilar, research grade (RSV)
Omalizumab biosimilar, research grade (IgE)
Eculizumab biosimilar, research grade (C5)
Please remember our product information: Adalimumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant: C003P.LA Syd Labs
Additional information
Ship from Country | USA |
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Size | 0.5 mg |