IPI-145

Background Information:

IPI-145 is an orally bioavailable PI3K/P110δ/γ isoform-specific
inhibitor, with Ki values: P110δ (23 pM), P110γ (243 pM), p110α (25900
pM) and p110β (1564 pM). IPI-145 exerts profound effects on adaptive and
innate immunity by inhibiting B and T cell proliferation, blocking
neutrophil migration, and inhibiting basophil activation. IPI-145 showed
potent activity in collagen-induced arthritis, ovalbumin-induced
asthma, and systemic lupus erythematosus rodent models (ref 1).

Reference:

1. D. G Winkler, et al, PI3K-δ and PI3K-γ inhibition by IPI-145
abrogate immune responses and suppresses activity in autoimmune and
inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74.*the
optical purity (e.e) of the product offered by some vendors is TOO POOR
to be reported in their Certificate of Analysis.

APIM050175: IPI-145

CAS No.: 1201438-56-3.
Molecular Formula: C₂₂H₁₇ClN₆O ? 0.5H₂O.
Molecular Weight: 425.9.
Purity: >99% chem and optical purity (HPLC and Chiral HPLC).
QC: ¹HNMR, HPLC-MS and Chiral HPLC.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.