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Description
Background Information:
CEP-37440 is a highly potent, selective and orally active inhibitor of ALK (Ezymatic IC50: 3.5 nM , Cellular IC50: 40 nM , Cellular IC50 in 75% human plasma: 120 nM) and FAK (Ezymatic IC50: 2.3 nM , Cellular IC50: 88 nM ), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK /FAK mediated human cancer cells and tumor xenograft models in mice. It is currently in clinical trials.
Reference:
1. M. J. Jacobs, et al, Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor, WO2013134353 A1*The product has been through a thorough analysis by HPLC-MS, Chiral HPLC, NMR and Quantitative Elemental Analysis, is offered as HCl salt (1.3 eq.), supported by a high-precision Quantitative Elemental Analysis.*Buyer beware: Other vendors, if not all, are selling this product as a racemic mixture (0% optical purity).
APIM050128: CEP-37440
CAS No.: 1391712-60-9.
Molecular Formula: C30H38ClN7O3?1.3 HCl.
Molecular Weight: 627.5.
Purity: >99% (HPLC at 214 and 254 nm), >99% optical purity (Chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis*.
Solubility: Soluble in DMSO; Water with 2.0 eq. of HCl.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Additional information
| Ship from Country | USA |
|---|---|
| Size | 10 mg, 100 mg, 200 mg, 50 mg |
