C-FOS Polyclonal Antibody
$250.00 – $350.00
Conditions of optimal C-FOS polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA000542-R12-2090 |
|---|---|
| Product Name | C-FOS Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Specificity/Sensitivity | c-Fos antibody detects endogenous levels of c-Fos. |
| Reactivity | Human, Mouse, Rat. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human c-Fos. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation. |
| Form Of Antibody | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal C-FOS antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA000542-R12-2090: c-Fos Polyclonal Antibody
Background
The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ)murine osteosarcoma virus which was mapped to a single human chromosome.1 c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family.c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth,differentiation, and transformation.2 Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating thedifferentiation and activity of specific bone cell populations, both during normal development and in bone disease.
Other C-FOS Antibody:
C-FOS Polyclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 50 ug |
