MAP2K7 Polyclonal Antibody
$350.00
Conditions of optimal MAP2K7 polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA002255-PA1922 |
|---|---|
| Product Name | MAP2K7 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | EC 2.7.12.2; MAP kinase kinase 7; MAPKK 7; MAPK/ERK kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2 |
| Isotype | Rabbit IgG. |
| Reactivity | Human, Rat, Mouse; |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminal of human MAP2K7, identical to the related rat and mouse sequences. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Lyophilized. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal MAP2K7 Antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA002255-PA1922: MAP2K7 Polyclonal Antibody
Introduction
MAP2K7(Mitogen-activated protein kinase kinase 7), also known as MAP kinase kinase 7, MAPKK7, JNKK2, PRKMK7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene. This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different isoforms with three possible N-termini and two possible C-termini (1 and 2 isoforms). Schramek et al. (2011) showed that the doxorubicin-mediated DNA damage response in human A549 lung carcinoma cells caused rapid phosphorylation and upregulation of p53 (TP53). MKK7 knockdown reduced p53 phosphorylation, delayed p53 upregulation, and interfered with cell cycle arrest at G2/M. MKK7 was activated in primary lung tumors, and tumors with a p53 mutation showed even higher MKK7 phosphorylation. Schramek et al. (2011) concluded that MKK7 exerts its tumor suppressive function through p53.
Other MAP2K7 Antibody:
MAP2K7 (Ab-271) Polyclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
