MAP3K1 Polyclonal Antibody
$350.00
Conditions of optimal MAP3K1 polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA002256-PA1923 |
|---|---|
| Product Name | MAP3K1 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1 |
| Isotype | Rabbit IgG. |
| Reactivity | Human, Rat, Mouse. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminal of human MAP3K1, identical to the related rat and mouse sequences. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Lyophilized. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal MAP3K1 antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA002256-PA1923: MAP3K1 Polyclonal Antibody
Introduction
MAP3K1(Mitogen-activated protein kinase kinase kinase 1), also known as MEKK1, MAPKKK1,MEK KINASE or MAP/ERK KINASE KINASE 1, is an enzyme that in humans is encoded by the MAP3K1 gene. Vinik et al. (1995) identified DNA sequence and size polymorphisms in intronic and 3-prime untranslated regions of the mouse Map3k1 gene and the human MAP3K1 homolog. Using these allele-specific polymorphisms, they mapped the Map3k1 gene in an intersubspecific backcross to mouse chromosome 13. They mapped the human MAP3K1 gene to chromosome 5 by somatic cell hybrid analysis. By assaying transfected COS-1 cells, Xia et al. (1998) showed that human MEKK1 activated JNK1 (MAPK8) robustly and p38-alpha (MAPK14) less efficiently, but it had only a marginal effect on ERK2 (MAPK1). MEKK1 directly and specifically interacted with JNKK1 (MAP2K4) and activated JNKK1 in cells and in vitro. Phosphorylation of JNKK1 by MEKK1 disrupted their interaction. MEKK1 and JNK1 competed for binding to JNKK1. Xia et al. (1998) concluded that JNKK1 is the preferred MEKK1 substrate.
Other MAP3K1 Antibody:
MAP3K1 Polyclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
