Infliximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
$375.00
Infliximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant (anti-human TNF alpha monoclonal antibody) is used for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by infliximab.
Synonyms: Tumor necrosis factor, TNF, cachexin, cachectin, tumor necrosis factor alpha, TNFα
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| Catalog No. | C011P-AAG |
|---|---|
| Product Name | Infliximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Source/Host | The anti-human TNF alpha monoclonal antibody Infliximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade Infliximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human TNF alpha. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by Infliximab. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.2, no stabilizers or preservatives. |
| Endotoxin | < 0.1 EU per 1 ug of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The recombinant monoclonal antibody Infliximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Infliximab biosimilar CHO stable cell line is available for licensing to manufacture the Infliximab biosimilar protein. The research grade infliximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
C011P-AAG: Infliximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Chimeric IgG1 Monoclonal Antibody.
Background
Infliximab, a chimeric anti-TNF-α monoclonal antibody, is used to treat psoriasis, Crohn’s disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. Infliximab interferes TNF-α from binding to its receptor in the cell.
Mainly produced by activated macrophages (M1), Tumor necrosis factor (TNF, cachexin, cachectin, tumor necrosis factor alpha, TNFα) plays important roles in the regulation of autoimmune reaction.
Syd Labs also provides the following anti-TNF antibody biosimilar protein:
Adalimumab Biosimilar, research grade, anti-human TNF / TNF-α monoclonal antibody
Adalimumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Pateclizumab Biosimilar, research grade, anti-human TNFSF / LT-α / TNF monoclonal antibody
Tabalumab Biosimilar, research grade, anti-human TNF / TNFSF / BAFF monoclonal antibody
Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.
Infliximab Biosimilar, Research Grade, Anti-human TNF alpha / TNFSF / TNF-α monoclonal antibody
Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:
In vivo grade recombinant human IgG1 isotype control antibody
In vivo grade recombinant human IgG1 Fc protein
In vivo grade recombinant human IgG1-D265A isotype control antibody
In vivo grade recombinant human IgG1-N297A isotype control antibody
In vivo grade recombinant human IgG1-D265A N297A isotype control antibody
In vivo grade recombinant human IgG1-L234A L235A P329G (LALAPG) isotype control antibody
Frequent questions related to “Infliximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant”:
What is infliximab?
How does infliximab work?
What is the mechanism of action for infliximab?
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Additional information
| Ship from Country | USA |
|---|---|
| Size | 0.5 mg |