Eculizumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
$375.00
Eculizumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant (anti-human C5 monoclonal antibody) is used for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by eculizumab.
Synonyms: the terminal Complement component 5
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| Catalog No. | C022P-AAG |
|---|---|
| Product Name | Eculizumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Source/Host | The anti-human C5 monoclonal antibody Eculizumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade Eculizumab biosimilar 234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human C5, the terminal complement component 5. |
| Applications | ELISA, functional assays such as bioanalytical PK and ADA assays. |
| Form Of Antibody | 0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives. |
| Endotoxin | < 0.1 EU per 1 ug of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The recombinant monoclonal antibody Eculizumab L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Eculizumab biosimilar CHO stable cell line is available for licensing to manufacture the eculizumab biosimilar protein. The research grade eculizumab biosimilar protein is for research use only (RUO). Recombinant human IgG4 isotype controls and recombinant human IgG2 isotype controls are available. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
C022P-AAG: Eculizumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Humanized IgG2 Monoclonal Antibody.
Background
Eculizumab, a recombinant humanized anti-C5 (the terminal Complement component 5) monoclonal antibody, selectively targets and inhibits the terminal portion of the complement cascade. Eculizumab is a first-in-class terminal complement inhibitor to treat paroxysmal nocturnal hemoglobinuria (PNH) with excessive destruction of red blood cells (hemolysis). Eculizumab is also the first agent to treat atypical hemolytic uremic syndrome (aHUS) with abnormal blood clots to form in small blood vessels throughout the body, leading to kidney failure, damage to other vital organs and premature death.
Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.
Eculizumab Biosimilar (Research Grade), Anti-human C5 Monoclonal Antibody
Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls.
In vivo grade recombinant human IgG2 isotype control antibody
In vivo grade recombinant human IgG2 Fc protein
In vivo grade recombinant human IgG4 S228P isotype control antibody
In vivo grade recombinant human IgG4 Fc protein
In vivo grade recombinant human IgG4-S228P L235E P329G (SPLEPG) isotype control antibody
Frequent questions related to “research grade eculizumab biosimilar, anti-human C5 monoclonal antibody”:
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Additional information
| Ship from Country | USA |
|---|---|
| Size | 0.5 mg |