TrkA (Ab-701) Polyclonal Antibody
$250.00 – $350.00
Conditions of optimal TrkA (ab-701) polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA000545-B8070 |
|---|---|
| Product Name | TrkA (Ab-701) Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | Neurotrophic tyrosine kinase receptor A |
| Specificity/Sensitivity | Trk A antibody detects endogenous levels of total Trk A protein. |
| Reactivity | Human, Mouse, Rat. |
| Immunogen | The antiserum was produced against synthesized peptide derived from Internal of human Trk A. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal TrkA antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA000549-B8070: TrkA (Ab-701) Polyclonal Antibody
Background
Trk A (Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin,Nerve Growth Factor (NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA(NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or ‘preferred by’ NGF, NTF4(Neurotrophin-4) and BDNF, and NTF3(Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA(NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform(s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes.1 Indo et al. (1996) concluded that defects in TRKA cause CIPA (Congenital insensitivity to pain with anhidrosis ) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect(s) of the nervous system.2
Other TrkA Antibodys:
TrkA Polyclonal Antibody
TrkA (Phospho-Tyr791) Polyclonal Antibody
TrkA (Phospho-Tyr496) Polyclonal Antibody
TrkA ELISA Kit:
Rat TrkA ELISA Kit
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 50 ug |
