TRAF2 Rabbit pAb

Catalog No.	A21636
Product Name	TRAF2 Rabbit pAb
Supplier Name	ABclonal, Inc.
Brand Name	Abclonal
Synonyms	TRAP; TRAP3; RNF117; MGC:45012
Gene Name	TRAF2
Protein Name	TRAF2
Uniprot/Swissprot ID	Q12933
Entrez GeneID	7186
Clonality	Polyclonal
Source/Host	Rabbit
Applications	WB
Reactivity	Human
Conjugate	Unconjugated
Note	Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline	Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Additional information

Ship from Country	USA
Size	20 ul, 100 ul, 200 ul, 50 ul

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