p57KIP2 Polyclonal Antibody
$350.00
Conditions of optimal p57KIP2 polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA002885-PA1876 |
|---|---|
| Product Name | p57KIP2 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | CDKN1C, CDN1C, CDNC, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, KIP2 |
| Isotype | Rabbit IgG. |
| Reactivity | Rat, Mouse. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminal of mouse CDKN1C, identical to the related rat sequence, and different from the related human sequence by two amino acids. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Lyophilized. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal p57 Kip2 antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA002885-PA1876: p57KIP2 Polyclonal Antibody
Introduction
CDKN1C(Cyclin-dependent kinase inhibitor 1C) also called p57(KIP2) or KIP2, is a protein which in humans is encoded by the CDKN1C imprinted gene. The CDKN1C gene encodes p57(KIP2), a potent tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. The CDKN1C gene is paternally imprinted, with preferential expression of the maternal allele. Matsuoka et al. (1995) demonstrated that the CDKN1C gene is located on chromosome 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, making it a tumor suppressor candidate. The CDKN1C gene contains 3 exons. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndromesuggesting that it is a tumor suppressor candidate. Diaz-Meyer et al. (2005) concluded that CDKN1C may be downregulated by multiple mechanisms including some that do not involve promoter methylation.
Other p57 Kip2 Antibodies:
p57KIP2 Polyclonal Antibody
p57 Kip2 (Ab-310) Polyclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
