DNA topoisomerase II alpha (TOP2A) Rabbit pAb

DNA topoisomerase II alpha (TOP2A) Rabbit pAb

$108.00$488.00

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$108.00$488.00

TOP2; TP2A; TOPIIA; TOP2alpha

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SKU: A0726
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Catalog No. A0726
Product NameDNA topoisomerase II alpha (TOP2A) Rabbit pAb
Supplier Name ABclonal, Inc.
Brand Name Abclonal
Synonyms TOP2; TP2A; TOPIIA; TOP2alpha
Gene Name TOP2A
Protein Name TOP2A
Uniprot/Swissprot ID P11388
Entrez GeneID 7153
Clonality Polyclonal
Source/Host Rabbit
Applications IF/ICC
Reactivity Human
Conjugate Unconjugated
Note Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Additional information

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USA

Size

20 ul, 100 ul, 200 ul

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