TFAM Polyclonal Antibody
$350.00
Conditions of optimal TFAM polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA003525-PA1936 |
|---|---|
| Product Name | TFAM Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | RTEF1, TCF13L1, TEA domain family member 4, TEAD-4, TEAD4, TEF3, transcription factor RTEF-1 |
| Isotype | Rabbit IgG. |
| Reactivity | Human. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminal of human TFAM. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Lyophilized. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal TFAM antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA003525-PA1936: TFAM Polyclonal Antibody
Introduction
TFAM(Transcription factor A, mitochondrial), also known as TCF6 or TCF6L2, is a 162-amino acid protein that activates transcription of each mitochondrial DNA (mtDNA) strand by binding to an element of approximately 30 nucleotides present in both the light-strand and the heavy-strand promoters. By Southern blot analysis of restriction enzyme digests of human/Chinese hamster somatic cell hybrid lines, Milatovich et al. (1992) mapped TFAM sequences, which they called MTTF1, to 3 different chromosomes: chromosomes 10, 7p, and 11q. By PCR-based screening of a somatic cell hybrid panel and by fluorescence in situ hybridization, Scott (2007) stated that the sequences mapped to chromosomes 7p (TCF6L1) and 11q (MTTF1, or TCF6L3) are pseudogenes. Larsson et al. (1997) mapped the mouse mitochondrial transcription factor A gene (Tfam) to the central part of mouse chromosome 10. This region exhibits syntenic homology with human 10q21. Mitochondrial transcription factor A is a key activator of mitochondrial transcription in mammals. It also has a role in mitochondrial DNA replication, since transcription generates an RNA primer necessary for initiation of mtDNA replication.
Other TFAM Antibody:
TFAM Polyclonal Antibody
TFAM Protein:
Recombinant Human TFAM Protein
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
