TBC1D4 Rabbit pAb

Phospho-Myosin Light Chain 2-S19 Rabbit mAbPhospho-Myosin Light Chain 2-S19 Rabbit mAb

TBC1D4 Rabbit pAb

$108.00$488.00

In stock

$108.00$488.00

AS160; NIDDM5

Store
SKU: A18216
Clear
View cart
Catalog No. A18216
Product NameTBC1D4 Rabbit pAb
Supplier Name ABclonal, Inc.
Brand Name Abclonal
Synonyms AS160; NIDDM5
Gene Name TBC1D4
Protein Name TBC1D4
Uniprot/Swissprot ID O60343
Entrez GeneID 9882
Clonality Polyclonal
Source/Host Rabbit
Applications WB, IF/ICC
Reactivity Mouse, Rat
Note Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Additional information

Ship from Country

USA

Size

20 ul, 100 ul, 200 ul, 50 ul

No more offers for this product!