Phospho-Raf1-S621 Rabbit pAb
$128.00 – $548.00
NS5; CRAF; Raf-1; c-Raf; CMD1NN
- Product Details
- Description
- Additional information
- More Offers
| Catalog No. | AP0087 |
|---|---|
| Product Name | Phospho-Raf1-S621 Rabbit pAb |
| Supplier Name | ABclonal, Inc. |
| Brand Name | Abclonal |
| Synonyms | NS5; CRAF; Raf-1; c-Raf; CMD1NN |
| Gene Name | RAF1 |
| Protein Name | RAF1 |
| Uniprot/Swissprot ID | P04049 |
| Entrez GeneID | 5894 |
| Clonality | Polyclonal |
| Source/Host | Rabbit |
| Applications | WB, IP |
| Reactivity | Human |
| Conjugate | Unconjugated |
| Note | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Additional information
| Ship from Country | USA |
|---|---|
| Size | 20 ul, 100 ul, 200 ul, 50 ul |