PEBP1 Polyclonal Antibody
$350.00
Conditions of optimal PEBP1 polyclonal antibody performance should be determined experimentally by the investigator.
- Product Details
- Description
- Additional information
- More Offers
| Catalog No. | PA002930-PA1713 |
|---|---|
| Product Name | PEBP1 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | Phosphatidylethanolamine-binding protein 1,PEBP-1; Prostatic-binding protein; HCNPpp; Neuropolypeptide h3 |
| Isotype | Rabbit IgG. |
| Reactivity | Rat, Mouse. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminal of mouse PEBP1, identical to the related rat sequence. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Lyophilized. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal PEBP1 antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA002930-PA1713: PEBP1 Polyclonal Antibody
Introduction
PEBP1(Phosphatidylethanolamine-binding protein 1), also called PBP, RKIP, inhibits the phosphorylation and activation of MEK by RAF1. PEBP1 is identical to the phosphatidylethanolamine-binding protein (PBP) with a relative molecular mass of 23 kD. The PEBP1 gene is mapped on 12q24.23. PEBP1 coimmunoprecipitates with RAF1 and MEK from cell lysates and colocalizes with RAF1 when examined by confocal microscopy. PEBP1 overexpression interferes with the activation of MEK and ERK, induction of AP1-dependent reporter genes, and transformation elicited by an oncogenically activated RAF1 kinase. PEBP1 expression was rapidly upregulated during induction of chemotherapy-triggered apoptosis in human prostate and breast cancer cell lines, and maximal RKIP expression correlated perfectly with the onset of apoptosis by Chatterjee et al(2004). RKIP depletion decreased the mitotic index, the number of metaphase cells, traversal times from nuclear envelope breakdown to anaphase, and an override of mitotic checkpoints induced by spindle poisons.
Other PEBP1 Antibodies:
PEBP1 Polyclonal Antibody
PEBP1 Polyclonal Antibody
PEBP1 Protein:
Recombinant Human PEBP1 Protein
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
