OSM Polyclonal Antibody
$350.00
Conditions of optimal OSM polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA006641-PA1668 |
|---|---|
| Product Name | OSM Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | ONCOSTATIN M |
| Isotype | Rabbit IgG. |
| Reactivity | Human. |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human OSM. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Lyophilized. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal OSM antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA006641-PA1668: OSM Polyclonal Antibody
Introduction
OSM?ONCOSTATIN M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The direction of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.
OSM Proteins:
Recombinant Rat OSM Protein
Recombinant Mouse OSM Protein
Recombinant Human OSM Protein, His Tag
Recombinant Human OSM Protein, HEK
Recombinant Human OSM Protein (209 a.a.)
Recombinant Human OSM Protein
Recombinant Human OSM Protein
Recombinant Human OSM Protein
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
