OLR1 Polyclonal Antibody
$350.00
Conditions of optimal OLR1 polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA006681-PA1833 |
|---|---|
| Product Name | OLR1 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | oxidized low density lipoprotein (lectin-like) receptor 1, CLEC8A, LOX-1, SCARE1 |
| Isotype | Rabbit IgG. |
| Reactivity | Human, Rat. |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human OLR1, different from the related rat sequence by three amino acids. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Lyophilized. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal OLR1 Antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA006681-PA1833: OLR1 Polyclonal Antibody
Introduction
OLR1(oxidized low density lipoprotein (lectin-like) receptor 1) also called CLEC8A, LOX-1, SCARE1, is a receptor protein which belongs to the C-type lectin superfamily. The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (OxLDL).The OLR1 gene is mapped on 12p13.2. Incubation of the cells with LDL had no effect on LOX1 expression, but incubation with OxLDL resulted in a dose-dependent increase in LOX1 mRNA and protein expression; however, very high concentrations of OxLDL caused a decrease in OxLDL expression, perhaps indicating toxic effects on endothelial cells. LOX1 was also expressed in macrophages, but not in vascular smooth muscle cells. The findings suggested a role for LOX1 in the pathophysiology of atherosclerotic cardiovascular disease.LOX1 expression was detected in all choroidal neovascular membranes, regardless of structure, whereas there was no evidence of LOX1 within the posterior segments of normal eyes. LOX1 plays an active role in the pathogenesis of choroidal neovascularization, especially in ARMD.
Other OLR1 Antibody:
OLR1 Polyclonal Antibody
OLR1 Proteins:
Recombinant Human OLR1 Protein
Recombinant Human OLR1 Protein
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
