NOS1 Polyclonal Antibody
$350.00
Conditions of optimal NOS1 polyclonal antibody performance should be determined experimentally by the investigator.
- Product Details
- Description
- Additional information
- More Offers
| Catalog No. | PA000069-PA1329 |
|---|---|
| Product Name | NOS1 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | Nitric Oxide Synthase 1 Antibody |
| Isotype | Rabbit IgG. |
| Specificity/Sensitivity | Human, rat. No cross reactivity with other proteins. |
| Reactivity | Human, Mouse, Rat. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminal of human NOS1 (1418-1434aa), identical to the related rat sequence. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05mg NaN3. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal NOS1 antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA000069-PA1329: NOS1 Polyclonal Antibody
Background
Nitric Oxide Synthase 1(NOS1,neuronal NOS,nNOS1) is a messenger molecule, mediating the effect ofendothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. It may be involved in neuronal cell death and damage in neurological illness. nNOS1 localized to the 12q24.2 region of human chromosome 12. It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098 amino acids. nNOS cDNA clones were shown to contain different 5′ terminal exons spliced to a common exon 2.Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300 bp of each other but separated from exon 2 by an intron that is at least 20 kb in length. The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle. The novel gaseous neuromediator nitric oxide is thought to play an important role in development and plasticity. Despite this, gene-knockout mice lacking neuronal (Type I) nitric oxide synthase exhibit relatively normal brain development and behavior.
Other NOS1 Antibodies:
NOS1 Polyclonal Antibody
Nitric Oxide Synthase, Brain (1-181) NOS1 Monoclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
