NMDAR1 Polyclonal Antibody
$350.00
Conditions of optimal NMDAR1 polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA000198-PA1222 |
|---|---|
| Product Name | NMDAR1 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | NMDA Receptor 1 Antibody |
| Isotype | Rabbit IgG. |
| Specificity/Sensitivity | Rat, mouse. No cross reactivity with other proteins. |
| Reactivity | Human, Mouse, Rat. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminal of human NMDAR1, identical to the related rat and mouse sequence. |
| Purification | Immunogen affinity purified. |
| Form Of Antibody | Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal NMDAR1 antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA000198-PA1222: NMDAR1 Polyclonal Antibody
Background
The NMDA receptor (NMDAR) is a specific type of ionotropic glutamate receptor. NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties.1 It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins ‘even-skipped’.2 The gene is a candidate for the site of the mutation in torsion dystonia.3, 4 The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.
Other NMDAR1 Antibodies:
NMDAR1 Polyclonal Antibody
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NMDAR1 (Ab-897) Polyclonal Antibody
NMDAR1 (Ab-896) Polyclonal Antibody
NMDAR1 (Ab-890) Polyclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug |
