CPB2 Polyclonal Antibody
$250.00 – $350.00
Conditions of optimal CPB2 polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA001306-R12-2647 |
|---|---|
| Product Name | CPB2 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | carboxypeptidase B2; carboxypeptidase U; CBPB2; CPU; EC 3.4.17.20; plasma carboxypeptidase B; TAFI |
| Specificity/Sensitivity | CPB2 antibody detects endogenous levels of CPB2. |
| Reactivity | Human. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CPB2. |
| Purification | The antibody was affinity-purified from rabbit anti-serum by immunogenic peptide affinity-chromatography. |
| Form Of Antibody | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal CPB2 antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA001306-R12-2647: CPB2 Polyclonal Antibody
Introduction
Carboxypeptidase B2 (CPB2) also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB), or thrombin-activatable fibrinolysis inhibitor (TAFI) is an enzyme that in humans is encoded by the CPB2 gene. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis.
Other CPB2 Antibody:
CPB2 Polyclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 50 ug |
