CHRM2 Polyclonal Antibody
$250.00 – $350.00
Conditions of optimal CHRM2 polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA001182-R12-2615 |
|---|---|
| Product Name | CHRM2 Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | Muscarinic acetylcholine receptor M2;CHRM2 |
| Specificity/Sensitivity | CHRM2 antibody detects endogenous levels of CHRM2. |
| Reactivity | Human, Mouse, Rat. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHRM2. |
| Purification | The antibody was affinity-purified from rabbit anti-serum by immunogenic peptide affinity-chromatography. |
| Form Of Antibody | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal CHRM2 antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA001182-R12-2615: CHRM2 Polyclonal Antibody
Background
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor. The M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system, by slowing the speed of depolarization. The CHRM2 gene inhibits the release of acetylcholine from cholinergic fibers in the lungs and elsewhere. In airway parasympathetic neurons, it is decreased by viral infections and by interferon-gamma, increasing actylcholine release. This gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, Gosso MF et al. genotyped three single-nucleotide polymorphisms (SNPs) in the CHRM2 gene on 7q31-35. CHRM2 is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.
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CHRM2 Polyclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 50 ug |
