CBL (Ab-774) Polyclonal Antibody
$250.00 – $350.00
Conditions of optimal CBL (ab-774) polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA001036-B0464 |
|---|---|
| Product Name | CBL (Ab-774) Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | CBL E3 ubiquitin protein ligase, CBL2, EC 6.3.2.-, Proto-oncogene c-CBL, Signal transduction protein CBL |
| Specificity/Sensitivity | CBL (Ab-774) antibody detects endogenous levels of total CBL protein. |
| Reactivity | Human, Mouse, Rat. |
| Immunogen | The antiserum was produced against synthesized non-phosphopeptide derived from human CBL around the phosphorylation site of tyrosine 774 (D-G-YP-D-V). |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Form Of Antibody | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal CBL antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA001036-B0464: CBL (Ab-774) Polyclonal Antibody
Background
CBL(Cbl proto-oncogene) is also known as C-CBL, RNF55, CBL2 and E3 ubiquitin protein ligase. Wei et al. (1990) mapped the CBL gene to chromosome 11q23.3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Other CBL Antibodys:
CBL Polyclonal Antibody
CBL (Ab-700) Polyclonal Antibody
CBL (Ab-674) Polyclonal Antibody
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 50 ug |
