CALR Polyclonal Antibody
$250.00 – $350.00
Conditions of optimal CALR polyclonal antibody performance should be determined experimentally by the investigator.
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| Catalog No. | PA000988-C10495 |
|---|---|
| Product Name | CALR Polyclonal Antibody |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Synonyms | CALR, CRP55, CRTC, Calreticulin precursor, ERp60, HACBP, grp60 |
| Specificity/Sensitivity | CALR antibody detects endogenous levels of total CALR protein. |
| Reactivity | Human, Mouse, Rat. |
| Immunogen | The antiserum was produced against synthesized peptide derived from internal of human CALR. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Form Of Antibody | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Stability & Storage | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Note | Conditions of optimal CALR antibody performance should be determined experimentally by the investigator. |
| Order Offline | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
Description
PA000988-C10495: CALR Polyclonal Antibody
Introduction
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen.
Other CALR Protein:
Recombinant Human Calreticulin Protein
Additional information
| Ship from Country | USA |
|---|---|
| Size | 100 ug, 50 ug |
