Trastuzumab Biosimilar, Mouse IgG1
$375.00
The cheapest research grade trastuzumab biosimilar (anti-human HER2 monoclonal antibody, mAb, clone 4D5-8) for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by trastuzumab. The research grade trastuzumab biosimilar protein is for research use only.
Synonyms: Receptor tyrosine-protein kinase erbB-2, CD340, cluster of differentiation 340, proto-oncogene Neu, Erbb2 (rodent), ERBB2 (human), erythroblastic oncogene B 2, human epidermal growth factor receptor 2.
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| Catalog No. | C009P.m1 |
|---|---|
| Product Name | Trastuzumab Biosimilar, Mouse IgG1 |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Clone | 4D5-8. |
| Source/Host | The anti-human HER2 monoclonal antibody trastuzumab biosimilar was produced in the trastuzumab biosimilar CHO stable cell line. |
| Specificity/Sensitivity | The research grade trastuzumab biosimilar specifically binds to the human HER2 / ErbB-2 / c-neu. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by trastuzumab. |
| Form Of Antibody | 0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The research grade trastuzumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | The research grade trastuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Trastuzumab biosimilar (clone huMAb 4D5-8) is the humanized anti-human HER2 mouse monoclonal antibody (clone muMAb 4D5). |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
C009P: Trastuzumab Biosimilar (Research Grade), Anti-human HER2 Monoclonal Antibody
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate.
There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions; when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.
Syd Labs also provides the following anti-ErbB/HER antibody biosimilar proteins:
Cetuximab biosimilar, research grade, anti-human EGFR monoclonal antibody
Cetuximab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Panitumumab biosimilar, research grade, anti-human EGFR monoclonal antibody
Panitumumab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Pertuzumab Biosimilar, research grade, anti-human Her2 monoclonal antibody
Pertuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.
Trastuzumab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls . Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:
In vivo grade recombinant human IgG1 isotype control antibody
In vivo grade recombinant human IgG1 Fc protein
In vivo grade recombinant human IgG1-D265A isotype control antibody
In vivo grade recombinant human IgG1-N297A isotype control antibody
In vivo grade recombinant human IgG1-D265A N297A isotype control antibody
In vivo grade recombinant human IgG1-L234A L235A P329G (LALAPG) isotype control antibody
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Does trastuzumab bind mouse HER2?
Is trastuzumab humanized?
What is the mechanism of action for trastuzumab?
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Additional information
| Ship from Country | USA |
|---|---|
| Size | 0.5 mg |