Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

$375.00

In stock

$375.00

Trastuzumab biosimilar with the L234A L235A P329G (LALAPG) Fc silent mutation (anti-human HER2 monoclonal antibody, mAb, clone 4D5-8) for in vitro and in vivo assays to study human HER2 biological pathways. The trastuzumab biosimilar with the wild type Fc, the corresponding human IgG1 isotype controls and mutants, and the antibody dilution buffer are also available.

Synonyms: Receptor tyrosine-protein kinase erbB-2, CD340, cluster of differentiation 340, proto-oncogene Neu, Erbb2 (rodent), ERBB2 (human), erythroblastic oncogene B 2, human epidermal growth factor receptor 2.

SKU: C009P-AAG
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Catalog No. C009P-AAG
Product NameTrastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Supplier Name Syd Labs, Inc.
Brand Name Syd Labs
Clone 4D5-8.
Source/Host The anti-human HER2 monoclonal antibody trastuzumab biosimilar with the Fc silent mutation by L234A L235A P329G (LALAPG) was produced in mammalian cells.
Specificity/Sensitivity The trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human HER2 / ErbB-2 / c-neu.
Applications ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by trastuzumab.
Form Of Antibody 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin < 0.1 EU per 1 ug of the protein by the LAL method.
Purity >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping The trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note The research grade trastuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Trastuzumab biosimilar (clone huMAb 4D5-8) is the humanized anti-human HER2 mouse monoclonal antibody (clone muMAb 4D5).
Order Offline Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

C009P-AAG: Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

Recombinant Humanized IgG1 Monoclonal Antibody.

Background

Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate.

There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions; when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.

Syd Labs also provides the following anti-ErbB/HER antibody biosimilar proteins:

Cetuximab biosimilar, research grade, anti-human EGFR monoclonal antibody
Cetuximab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Panitumumab biosimilar, research grade, anti-human EGFR monoclonal antibody
Panitumumab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Pertuzumab Biosimilar, research grade, anti-human Her2 monoclonal antibody
Pertuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant

Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.

Research grade trastuzumab biosimilar, anti-human HER2 monoclonal antibody

Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:

In vivo grade recombinant human IgG1 isotype control antibody
In vivo grade recombinant human IgG1 Fc protein
In vivo grade recombinant human IgG1-L234A L235A P329G (LALAPG) isotype control antibody

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Additional information

Ship from Country

USA

Size

0.5 mg

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