Reversed-phase HPLC Services

Reversed-phase HPLC Services

N-terminal Protein Sequencing Service

N-terminal Protein Sequencing Service

Sequence Liability Identification Services

CatalogBS071-Sequence
Grouped product items
Product Name Quantity
Sequence Liability Identification Service (Catalog No.: BS071)
$0.00

Post-translational modifications such as glycosylation, deamidation, isomerization, and oxidation have the potential to reduce affinity/potency, stability, and homogeneity of an antibody, resulting in complications to downstream process development. Algorithms has been developed to identify sequences within antibody variable regions that could present potential liabilities to product quality. This can allow the investigator to select antibodies for further development that lack these potential liabilities, or to assess whether they can be eliminated early in the antibody engineering process.

General procedure of the antibody sequence liability identification service:

The antibody variable regions of both heavy chain (VH) and light chain (VL) are analyzed for liabilities including, but not limited to N-linked glycosylation, deamidation, isomerization, pyroglutamate formation, and oxidation.

Information required from clients:

Amino acid sequence of mature heavy and light chain variable regions (VH and VL).

Deliverable:

A. Report identifying potential sequence liabilities.

We also provide the following antibody sequencing services:
Cloning and Sequencing Heavy- and Light-chain Variable Regions (VH and VL) of Hybridoma or Clonal B Lines
Single B Cell Antibody Cloning and Sequencing Service
N-terminal Protein Sequencing Service
De novo Antibody Sequencing Service

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