Rituximab Biosimilar, Human IgG2

Rituximab Biosimilar, Human IgG2

$375.00

In stock

$375.00

The rituximab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant, can be used for ELISA, neutralization, in vitro and in vivo functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by rituximab. The research grade rituximab biosimilar protein, L234A L235A P329G (LALAPG) Fc silent mutant, is for research use only.

Synonyms: B-lymphocyte antigen CD20, MS4A1, B1, Bp35, CVID5, LEU-16, MS4A2, S7, membrane spanning 4-domains A1, FMC7, cluster of differentiate 20

SKU: C010P.h2
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Catalog No. C010P.h2
Product NameRituximab Biosimilar, Human IgG2
Supplier Name Syd Labs, Inc.
Brand Name Syd Labs
Source/Host The Fc silent rituximab was produced in the mammalian cells.
Specificity/Sensitivity The Fc silent rituximab specifically binds to the human TNF alpha.
Applications ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by rituximab.
Form Of Antibody 0.2 uM filtered solution, pH 6.5, no stabilizers or preservatives.
Endotoxin < 0.1 EU per 1 ug of the protein by the LAL method.
Purity >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping The Fc silent rituximab is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note The research grade rituximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Rituximab biosimilar CHO stable cell line is available for licensing to manufacture the rituximab biosimilar protein.
Order Offline Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

C010P-AAG: Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant

Recombinant Humanized IgG1-LALAPG (L234A L235A P329G) Monoclonal Antibody.

Background

B-lymphocyte antigen CD20 encoded by the MS4A1 gene is an activated-glycosylated phosphoprotein on the surface of all B-cells. The function of the membrane protein is to stimulate B-cell immune response, specifically against T-independent antigens though its natural ligand remains unknown. CD20 is important for the development and differentiation of B-cells into plasma cells. CD20 belongs to the membrane-spanning 4A family with common structural features, similar intron/exon splice boundaries, and unique expression patterns among hematopoietic cells and nonlymphoid tissues.

Rituximab, a chimeric anti-CD20 monoclonal antibody, destroys B cells and is used to treat diseases with excessive numbers of B cells, overactive B cells, or dysfunctional B cells, such as many lymphomas, leukemias, transplant rejection, and autoimmune disorders.

Syd Labs also provides the following research grade anti-CD20 antibody biosimilars:
Obinutuzumab Biosimilar, research grade, anti-human CD20 monoclonal antibody

Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.
Rituximab Biosimilar, research grade, anti-human CD20 monoclonal antibody

Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:

In vivo grade recombinant human IgG1 isotype control antibody
In vivo grade recombinant human IgG1 Fc protein
In vivo grade recombinant human IgG1-D265A isotype control antibody
In vivo grade recombinant human IgG1-N297A isotype control antibody
In vivo grade recombinant human IgG1-D265A N297A isotype control antibody
In vivo grade recombinant human IgG1-L234A L235A P329G (LALAPG) isotype control antibody

Frequent questions related to “Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant”:

Does rituximab bind mouse CD20?
Is rituximab humanized?
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Additional information

Ship from Country

USA

Size

0.5 mg

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