AZ5104

CD271 Unconjugated(111901) catalog number: 111901 Caprico Biotechnologies

AZ5104

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Description

Background Information:

AZ5104 is an active circulating metabolite of AZD9291. It shares the similar overall activity profile with AZD9219, but is more potent against mutant EGFR forms, while hitting the wild-type EGFR form at a lower concentration thus demonstrating a smaller selectivity margin compared with the parent. Like AZD9291, AZ5104 displays potent antitumor activities both in vitro and in vivo, and is clinically competent with the parent.

Reference:

1. D. Cross, et al., AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer, Cancer Discovery, September 2014, 4; 1046.

APIM050087: AZ5104

CAS No.: 1421373-98-9.
Molecular Formula: C27H31N7O2?0.3HCl.
Molecular Weight: 500.2.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

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USA

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10 mg, 100 mg, 200 mg, 50 mg, 500 mg

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