Panitumumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
$375.00
Panitumumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant (anti-human EGFR monoclonal antibody) is used for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by panitumumab.
Synonyms: epidermal growth factor receptor, EGF receptor, ErbB-1, HER1
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| Catalog No. | C012P-AAG |
|---|---|
| Product Name | Panitumumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Source/Host | The anti-EGFR monoclonal antibody panitumumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade panitumumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human EGFR, ErbB-1 and HER1. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by panitumumab. |
| Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| Endotoxin | < 0.1 EU per 1 ug of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The recombinant monoclonal antibody panitumumab L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Panitumab biosimilar CHO stable cell line is available for licensing to manufacture the panitumumab biosimilar protein. The research grade panitumab biosimilar protein is for research use only (RUO). Recombinant human IgG2 isotype controls are available. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
C012P-AAG: Panitumumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Humanized IgG2 Monoclonal Antibody.
Background
Panitumumab, a fully anti-EGFR (epidermal growth factor receptor, EGF receptor, ErbB-1 and HER1 in humans) human monoclonal antibody, is used for the treatment of refractory EGFR-expressing metastatic colorectal cancer in patients with non-mutated (wild-type) KRAS”.
Syd Labs also provides the following anti-ErbB/HER antibody biosimilar proteins:
Cetuximab biosimilar, research grade, anti-human EGFR monoclonal antibody
Cetuximab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Trastuzumab biosimilar, research grade, anti-human HER2 monoclonal antibody
Trastuzumab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Pertuzumab Biosimilar, research grade, anti-human Her2 monoclonal antibody
Pertuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.
Panitumumab Biosimilar, Anti-human EGFR Monoclonal Antibody
Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:
In vivo grade recombinant human IgG2 isotype control antibody
In vivo grade recombinant human IgG2 Fc protein
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Additional information
| Ship from Country | USA |
|---|---|
| Size | 0.5 mg |