MEKK3 Rabbit pAb

Phospho-Myosin Light Chain 2-S19 Rabbit mAbPhospho-Myosin Light Chain 2-S19 Rabbit mAb

MEKK3 Rabbit pAb

$108.00$488.00

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$108.00$488.00

MEKK3; MAPKKK3

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SKU: A16058
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Catalog No. A16058
Product NameMEKK3 Rabbit pAb
Supplier Name ABclonal, Inc.
Brand Name Abclonal
Synonyms MEKK3; MAPKKK3
Gene Name MAP3K3
Protein Name MAP3K3
Uniprot/Swissprot ID Q99759
Entrez GeneID 4215
Clonality Polyclonal
Source/Host Rabbit
Applications WB, IHC-P
Reactivity Human, Mouse, Rat
Conjugate Unconjugated
Note Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Additional information

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USA

Size

20 ul, 100 ul, 200 ul, 50 ul

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