Denosumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
$375.00
Denosumab biosimilar L234A L235A P329G (LALAPG) Fc Silent Mutant (anti-human RANKL monoclonal antibody) is used for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by denosumab.
Synonyms: RANK ligand
- Product Details
- Description
- Additional information
- More Offers
| Catalog No. | C004P-AAG |
|---|---|
| Product Name | Denosumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
| Supplier Name | Syd Labs, Inc. |
| Brand Name | Syd Labs |
| Source/Host | The anti-human RANKL monoclonal antibody denosumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant was produced in mammalian cells. |
| Specificity/Sensitivity | The in vivo grade denosumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human RANKL (RANK ligand) protein. |
| Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by denosumab. |
| Form Of Antibody | 0.2 uM filtered solution, pH 5.2, no stabilizers or preservatives. |
| Endotoxin | < 1 EU per 1 mg of the protein by the LAL method. |
| Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
| Shipping | The recombinant monoclonal antibody denosumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| Note | Denosumab biosimilar CHO stable cell line is available for licensing to manufacture the denosumab biosimilar protein. The research grade denosumab biosimilar protein is for research use only (RUO). Recombinant human IgG2 isotype controls are available. |
| Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
C004P-AAG: Denosumab Biosimilar, Anti-human RANKL Monoclonal Antibody, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Humanized IgG2 Monoclonal Antibody.
Background
Denosumab, a fully human monoclonal antibody, inhibits the RANKL (RANK ligand) protein, the primary signal for bone removal. Denosumab can be used for the treatment of osteoporosis, treatment-induced bone loss, bone metastases, multiple myeloma, and giant cell tumor of bone.
Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg.
Denosumab Biosimilar (Research Grade), Anti-human RANKL Monoclonal Antibody
Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:
In vivo grade recombinant human IgG2 isotype control antibody
In vivo grade recombinant human IgG2 Fc protein
Frequent questions related to “research grade Denosumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant”:
What is denosumab made of?
How does denosumab work?
What is the mechanism of action for denosumab?
Popular searches related to “Denosumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant”:
denosumab monoclonal antibody
denosumab purchase
denosumab mechanism of action
denosumab price
RANKL mouse cell line
RANKL
RANK Ligand
Additional information
| Ship from Country | USA |
|---|---|
| Size | 0.5 mg |