Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
$375.00
Cetuximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant (anti-human EGFR monoclonal antibody) is used for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by cetuximab.
Synonyms: epidermal growth factor receptor, EGF receptor, ErbB-1, HER1
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Catalog No. | C002P-AAG |
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Product Name | Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
Supplier Name | Syd Labs, Inc. |
Brand Name | Syd Labs |
Source/Host | The anti-human EGFR monoclonal antibody cetuximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant was produced in the cetuximab biosimilar CHO stable cell line. |
Specificity/Sensitivity | The in vivo grade cetuximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human EGFR. |
Applications | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by cetuximab. |
Form Of Antibody | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
Endotoxin | < 0.1 EU per 1 ug of the protein by the LAL method. |
Purity | >95% by SDS-PAGE under reducing conditions and HPLC. |
Shipping | The recombinant monoclonal antibody cetuximab L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
Note | The research grade cetuximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Cetuximab biosimilar CHO stable cell line is available for licensing to manufacture the cetuximab biosimilar protein. |
Order Offline | Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card. |
Description
C002P-AAG: Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Chimeric IgG1 Monoclonal Antibody.
Background
Cetuximab, a chimeric (mouse/human) anti-EGFR monoclonal antibody, is an EGFR inhibitor used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab binds to EGFR and turns off the uncontrolled growth in cancers with EGFR mutations.
Cetuximab can be used for treatment of KRAS wild type colon cancer but has little or no effect in colorectal tumors harboring a KRAS mutation. Before treatment using Erbitux, it is better to do a diagnosis using the real time PCR companion diagnostic test for KRAS, the therascreen KRAS test.
Syd Labs also provides the following anti-ErbB/HER antibody biosimilar proteins:
Trastuzumab biosimilar, research grade, anti-human HER2 monoclonal antibody
Trastuzumab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Panitumumab biosimilar, research grade, anti-human EGFR monoclonal antibody
Panitumumab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Pertuzumab Biosimilar, research grade, anti-human Her2 monoclonal antibody
Pertuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Syd Labs provides a number of research grade antibody biosimilar proteins with competitive prices starting from $3/mg. Syd Labs also introduces mutations to the antibody biosimilars including engineering or switching the isotypes or Fc engineering, such as Fc silent.
Cetuximab Biosimilar (Research Grade), Anti-human EGFR Monoclonal Antibody
Syd Labs also produces the in vivo grade isotype control antibodies. Some customers purchase them for in vitro assays such as flow cytometry or immunohistochemistry (IHC) because the prices are too good if compared to those research reagents of antibody isotype controls. Syd Labs provides the following in vivo grade recombinant human IgG1 kappa isotype control antibody proteins and mutants:
In vivo grade recombinant human IgG1 isotype control antibody
In vivo grade recombinant human IgG1 Fc protein
In vivo grade recombinant human IgG1-D265A isotype control antibody
In vivo grade recombinant human IgG1-N297A isotype control antibody
In vivo grade recombinant human IgG1-D265A N297A isotype control antibody
In vivo grade recombinant human IgG1-L234A L235A P329G (LALAPG) isotype control antibody
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Additional information
Ship from Country | USA |
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Size | 0.5 mg |