APH1A Rabbit pAb

Phospho-Myosin Light Chain 2-S19 Rabbit mAbPhospho-Myosin Light Chain 2-S19 Rabbit mAb

APH1A Rabbit pAb

$108.00$488.00

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$108.00$488.00

APH-1; APH-1A; CGI-78; 6530402N02Rik

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SKU: A14666
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Catalog No. A14666
Product NameAPH1A Rabbit pAb
Supplier Name ABclonal, Inc.
Brand Name Abclonal
Synonyms APH-1; APH-1A; CGI-78; 6530402N02Rik
Gene Name APH1A
Protein Name APH1A
Uniprot/Swissprot ID Q96BI3
Entrez GeneID 51107
Clonality Polyclonal
Source/Host Rabbit
Applications WB, IF/ICC
Reactivity Human, Mouse
Conjugate Unconjugated
Note Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
Order Offline Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

Description

This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer’s disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

Additional information

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USA

Size

20 ul, 100 ul, 200 ul, 50 ul

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