Anti-mouse TIGIT Monoclonal Antibody (Clone: 1F4) | PA007280.h1Fs

Catalog No.	PA007280.h1Fs
Product Name	Anti-mouse TIGIT Monoclonal Antibody (Clone: 1F4) | PA007280.h1Fs
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	VSIG9, VSTM3, WUCAM, T-cell immunoreceptor with Ig and ITIM domains, T cell immunoreceptor with Ig and ITIM domains
Clone	1F4.
Isotype	Human IgG1 kappa.
Source/Host	The anti-mouse TIGIT monoclonal antibody (clone: 1F4) was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade recombinant mouse monoclonal antibody (clone: 1F4) specifically binds to the mouse TIGIT protein.
Applications	ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TIGIT protein.
Immunogen	The original rat hybridoma (clone name: RMP1-14) was generated by immunizing Sprague Dawley rats with mouse PD-1-transfected BHK cells and using a P3U1 myeloma as the fusion partner.
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The In vivo Grade Recombinant Anti-mouse TIGIT Monoclonal Antibody (Clone: 1F4), Human IgG1 Fc Silent Kappa is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	Recombinant mouse IgG2a isotype controls and Recombinant human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007280.h1Fs: In vivo Grade Recombinant Anti-mouse TIGIT Monoclonal Antibody, Human IgG1 Fc Silent Kappa (Clone: 1F4)

Recombinant human IgG1 monoclonal antibody with Fc silent mutation.

Background

The 1F4 antibody binds to the TIGIT protein (WUCAM, Vstm3 or VSIG9), a novel immune checkpoint receptor with inhibitory function. TIGIT is expressed on T cells and natural killer (NK) cells, and several human cancers, including melanoma, NSCLC, and colorectal cancer. Similar to PD-1, the TIGIT receptor limits antitumor immune response in cancer.

Related Recombinant IgG Reference Antibodies:

In vivo grade recombinant mouse IgG2a isotype control antibody

Syd Labs provides the following recombinant anti-mouse TIGIT monoclonal antibodies:

In vivo grade recombinant anti-mouse TIGIT antibodies (clone 10A7)

Anti-mouse TIGIT Monoclonal Antibody (Clone: 1F4), Human IgG1 Fc Silent Kappa from: Anti-mouse TIGIT Monoclonal Antibody (Clone: 1F4), Human IgG1 Fc Silent Kappa: PA007280.h1Fs Syd Labs

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