Anti-human Siglec-2/CD22 Monoclonal Antibody (Clone: NCI m971) | PA007273.h1Fs

Catalog No.	PA007273.h1Fs
Product Name	Anti-human Siglec-2/CD22 Monoclonal Antibody (Clone: NCI m971) | PA007273.h1Fs
Supplier Name	Syd Labs, Inc.
Brand Name	Syd Labs
Synonyms	cluster of differentiation 22
Clone	NCI m971.
Isotype	Human IgG1 kappa.
Source/Host	The anti-human Siglec-2/CD22 monoclonal antibody (clone: NCI m971) was produced in mammalian cells.
Specificity/Sensitivity	The in vivo grade recombinant mouse monoclonal antibody (clone: NCI m971) specifically binds to the human Siglec-2/CD22 protein.
Applications	ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human Siglec-2/CD22 protein.
Form Of Antibody	0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Purity	>95% by SDS-PAGE under reducing conditions and HPLC.
Shipping	The In vivo Grade Recombinant Anti-human Siglec-2/CD22 Monoclonal Antibody (Clone: NCI m971), Human IgG1 Fc Silent Kappa is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
Note	Recombinant mouse IgG2a isotype controls and Recombinant human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Order Offline	Phone: 1-617-401-8149 Fax: 1-617-606-5022 Email: message@sydlabs.com Or leave a message with a formal purchase order (PO) Or credit card.

Description

PA007273.h1Fs: In vivo Grade Recombinant Anti-human Siglec-2/CD22 Monoclonal Antibody, Human IgG1 Fc Silent Kappa (Clone: NCI m971)

Recombinant human IgG1 monoclonal antibody with Fc silent mutation.

Background

The recombinant NCI m971 antibody binds to the human CD22 protein, a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer’s patches in mice. In mice, it has been shown that CD22 blockade restores homeostatic microglial phagocytosis in aging brains.

Anti-human Siglec-2/CD22 Monoclonal Antibody (Clone: NCI m971), Human IgG1 Fc Silent Kappa from: Anti-human Siglec-2/CD22 Monoclonal Antibody (Clone: NCI m971), Human IgG1 Fc Silent Kappa: PA007273.h1Fs Syd Labs

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